Principal UX Architect

Compensation: $156,000 - $200,000 per year. You are eligible for a Short-Term Incentive Plan with the target at 15% of your annual earnings; terms and conditions apply.

Principal UX Architect - Remote US

The Principal UX Architect will be the senior design leader responsible for shaping the user experience vision for Ambry Genetics’ suite of digital products, enabling healthcare providers, patients, and internal teams to efficiently and intuitively interact with genomic testing and data services. This role blends strategic UX leadership with hands-on product design, guiding solutions from concept through production deployment.

The ideal candidate will bring deep expertise in enterprise SaaS, workflow-heavy business applications, and data-rich scientific platforms, with the ability to unify the experience across multiple products—including provider portals, patient-facing platforms, real-time order tracking applications, and specialized scientific data management tools.

Essential Functions

• Establish and maintain a cohesive UX strategy, design system, and visual language for a multi-application ecosystem serving both external customers and internal teams
• Champion human-centered design principles and accessibility best practices
• Partner with leadership to ensure UX aligns with business goals, regulatory requirements, and scientific workflows
• Lead UX for high-impact applications across multiple domains, including:
• Provider and patient portals for test ordering, results delivery, and account management
• Internal and client-facing tools for managing and interpreting complex variant and genomic data
• Translate complex, data-intensive workflows into clear, efficient, and consistent interfaces
• Use modern design tools (Figma, Balsamiq) to create wireframes, prototypes, and high-fidelity UI
• Incorporate advanced capabilities such as intelligent search, workflow automation, and interactive data visualizations
• Conduct foundational and iterative research with healthcare providers, patients, and internal operational staff
• Run usability testing to identify pain points and validate solutions
• Leverage data and feedback to continuously optimize workflows and interfaces
• Partner with engineering leads to ensure design feasibility and fidelity through development
• Collaborate with product managers, business analysts, and QA to integrate UX into all phases of the development lifecycle
• Facilitate design workshops to align stakeholders on vision and execution
• Implement scalable design processes to increase early UX involvement in roadmap planning
• Develop reusable design patterns and components for speed, consistency, and maintainability
• Mentor other designers and foster a culture of design excellence and innovation
• Other duties as assigned

Qualifications

• Bachelor’s or Master’s degree in Human-Computer Interaction, Design, or related field or equivalent work experience
• 12+ years of UX/UI design experience, with 3+ years in a principal or lead-level role
• Proven success designing complex business- and consumer-facing applications with measurable business and user impact
• Strong portfolio showcasing concept-to-delivery leadership, design system development, and workflow problem-solving
• Proficiency in Figma, Balsamiq, or similar tools
• Ability to simplify and standardize complex workflows without losing necessary depth
• Strategic vision combined with hands-on execution capability
• Strong collaboration skills across scientific, technical, and business teams
• Proactive in identifying risks, dependencies, and opportunities for innovation

Preferred

• Experience in healthcare, life sciences, or other regulated industries
• Background in designing data-intensive platforms and multi-audience portals
• Familiarity with AI-powered features and front-end development principles
• Academic or professional background in a scientific discipline

#LI-SS1 #LI-REMOTE

About Us:

Ambry Genetics Corporation is a CAP-accredited and CLIA-licensed molecular genetics laboratory based in Aliso Viejo, California. We are a genetics-based healthcare company that is dedicated to open scientific exchange so we can work together to understand and treat all human disease faster.

At Ambry, everyone is welcome. A career at Ambry Genetics is a chance to be part of a dynamic company that aims to improve health by understanding the relationships between genetics and human disease. We earned our reputation as industry leaders by responsibly introducing cutting-edge genetic testing solutions and continually sharing what we learn with the global scientific community.

At Ambry you will be learning, challenging yourself, and having fun while collaborating with teammates through the open exchange of ideas. Our outstanding benefits program includes 401k, medical, dental, vision, FSA, paid sick leave and generous paid time off (PTO) program. Ambry Genetics is an Equal Opportunity Employer (EOE) and we maintain a drug-free work environment.

The Company believes in second chance employment. Qualified applicants with arrest or conviction history will be considered regardless of their arrest or conviction history, consistent with local laws such as Los Angeles County Fair Chance Ordinance and the California Fair Chance Act. You do not need to disclose your criminal history or participate in a background check until a conditional job offer is made to you. After making a conditional offer and running a background check, if the Company is concerned about conviction that is directly related to the job, you will be given the chance to explain the circumstances surrounding the conviction, provide mitigating evidence, or challenge the accuracy of the background report. For the purpose of the above job description, “Essential Functions” are “Material Job Duties”.

Our salary ranges are determined by role, level, and location. The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across all US locations. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training.

All qualified applicants will receive consideration for employment without regard to race (and traits historically associated with race, including, but not limited to hair texture and protective hairstyles such as braids, locks, and twists), color, creed, religion, sex, sexual orientation, gender identity, gender expression (including transgender status), national origin, ancestry, age, marital status or protected veteran status and will not be discriminated against on the basis of disability, protected medical condition as defined by applicable state or local law, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. If you have a disability or special need that requires accommodation, please contact us at ...

Ambry does not accept unsolicited resumes from individual recruiters, third party recruiting agencies, outside recruiters or firms without an executed contract in place. We are not responsible for any fees related to resumes that are unsolicited or are received by Ambry. Such resumes will be deemed the sole property of Ambry and will be processed accordingly.

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